Molecular Biology of Axons

Molecular Biology of Axons “A Turning Point…”

Previous studies have shown that dendrites and axons contain both mRNAs and the machinery for local protein translation. While a number of studies in recent years have focused on the functional role of protein synthesis in dendrites, relatively less is know about the role of local translation in axons. Campbell and Holt (this issue of Neuron) show that local protein synthesis and degradation ar...

Systems biology versus molecular biology

Systems biology and molecular biology can answer the same question in quite different ways, and frequently the answers given by one sub-discipline seem no answer at all to the other. For many molecular biologists, a systemslevel explanation leaves them feeling that, until the underlying molecular mechanisms are known, the approach is hopelessly superficial. For systems biologists, on the other ...

The 15th Iranian National Congress of Biochemistry & 6th International Congress of Biochemistry and Molecular Biology

Molecular biology of sarcomas

There are two types of sarcomas with regards to the type of molecular alterations: sarcomas with relatively simple, usually specific lesions and those with complex unspecific lesions. A molecular classification for sarcomas can therefore be proposed (Table 1). Recurrent chromosomal translocations: about 10-15% of all sarcomas bear a recurrent chromosomal translocation (Table 2). The most freque...

Molecular biology of cholesteatoma.

Cholesteatoma is a non-neoplastic, keratinizing lesion, characterized by the proliferation of epithelium with aberrant micro-architecture into the middle ear and mastoid cavity. The exact pathogenic molecular mechanisms behind the formation and propagation of cholesteatoma remain unclear. Immunohistochemical examinations of the matrix and perimatrix have considerably improved the knowledge of c...